Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment

The SPSAS Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment aims to improve the quality of translational cancer research training, and provide opportunities for students and fellows to expand their understanding. Despite tremendous advances in the understanding of their causes, cancer related deaths now exceed those from coronary heart disease and stroke, worldwide. In light of these statistics, it is obvious the need to accelerate the application of the advances in cancer research that have happened in the last 10 years into clinical practice, patient care, and prevention strategies. The school combines plenary sessions on broad cancer themes with state-of-the-art conferences, concurrent sessions, and mini-symposia.

Institution

Faculdade de Medicina / Universidade de São Paulo
Field of Knowledge

Medicine
Academic Director

Maria Aparecida Nagai
Grant Number

2012/50309-5
Date

2013-02-03 to 2013-02-08
Registration Deadline

closed
Site
City

São Paulo
Keywords

Translational research, Tumor microenvironment, Therapeutic targets, Oncology, Molecular biomarkers, Cancer

Program Hide

Day		Time
Feb 2^nd		14:00 – 17:30	Check in, credentials, material distribution
Sunday, February 3^rd FMUSP Theater	Plenary sessions 9:00 - 18:30	07:30 – 08:45	Check in, credentials, material distribution
		09:00 – 09:20	Opening Ceremony and Welcoming Remarks
			Prof. Dr. José Otávio Auler	Director in Office of Medical School, University of São Paulo (FMUSP)
			Prof Dr Giovanni Guido Cerri	Director of Medical School, University of São Paulo (FMUSP) Secretary of Health of the State of São Paulo
			Prof Dr Marco Antônio Zago	Pro-Chancellor of Research of the University of São Paulo (USP)
			Prof Dr José Eluf Neto	Executive Director of the Laboratories of Medical Investigation (LIMs)
			Prof Dr Flavio Fava de Moraes	Director of Medical School Foundation (FFM)
			Prof Dr Carlos Henrique de Brito Cruz	Scientific Director of Foundation for Research Support of São Paulo (FAPESP)
			Prof Dr Paulo Hoff	Head of Clinical Oncology- Medical School, University of São Paulo and ICESP Clinical Diretor
			Prof Dr Roger Chammas	Head of Basic Oncology- Medical School, University of São Paulo (FMUSP)
			Prof Dra Maria A Nagai	Associate Professor, Medical School, University of São Paulo (FMUSP)
		09:30 – 09:40	Paulo Hoff – Welcome note Head of Clinical Oncology- Medical School, University of São Paulo and ICESP Clinical Diretor, São Paulo, Brazil
		09:40 – 10:20	Carlos Henrique de Brito Cruz Diretor científico FAPESP, São Paulo, Brazil
		10:20 – 10:50	Marco Antônio Zago Pro-Chancellor of Research of the University of São Paulo (USP), São Paulo, Brazil
		10:50 – 11:20	Coffee break
		11:20 – 12:20	Opening conference Molecular Imaging and the tumor microenvironment Robert Gillies, Moffitt Cancer Center, Tampa, USA
		12:20 – 14:00	Lunch
			Chairs persons: José Eluf Neto
		14:00 – 15:00	Molecular and immunohistochemical markers of gastric carcinoma differentiation and progression. Maria de Fátima MH Carneiro – IPATIMUP, Porto, Portugal
		15:00 – 16:00	Triple-Negative Breast Cancer: an example for translational cancer research Fernando Schmitt, IPATMUP, Porto, Portugal
		16:00 – 16:30	Coffee break
		16:30 – 17:30	Hepatocellular carcinoma – advances in the integration of morphological and molecular aspects, towards a new classification useful for clinical decisions Park YN, Yonsei University College of Medicine, Seoul, Korea
		17:30 – 18:30	Role of biomarkers in cancer detection and patient management Michael J Duffy, School of Medicine & Medical Science, St Vincents University Hospital, Dublin, Ireland
	19:00 – 21:00 (ICESP)		Welcome Cocktail

Day		Time
Monday, February 4^th ICESP	Mini-courses 8:00 – 8:45	Room A		MC1 - Immunology for the non-immunologist José Alexandre Barbuto, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil
		Room B		MC2 - Principles of Clinical Research in Oncology Rachel Simoes Pimenta Riechelmann, ICESP, São Paulo, Brazil
		Room C		MC3 - 3D culture and mammary gland tumour engraftment as models for studying the biology and therapeutics Bruce Elliott, Queen’s University, Canada
	Concurrent sessions - Molecular biology of cancer: an update 09:00 – 12:30	Session 1: Breast cancer	Room A	Chair persons: M Mitzi Brentani and Maria A Nagai
			09:00 – 09:50	Introduction to mammary gland biology and breast cancer Paraic Kenny,Albert Einstein College of Medicine, Bronx, NY,USA
			09:50 – 10:30	The cancer Genome Atlas: Comprehensive molecular portraits of human tumros Katherine Hoadley Research Associated, Lineberger Comprehensive Cancer Center, Univ N Carolina, USA
			10:30 – 11:00	Coffee break
			11:00 – 11:30	Transcriptional profile as prognostic and predictive factor in breast cancer Maria A K Folgueira, Medical School, University of São Paulo, São Paulo, Brazil
			11:30 – 12:00	Molecular alterations mediated by BRCA1 mutations in triple-negative breast tumors Dirce M Carraro, A C Camargo Hospital, São Paulo, Brazil
			12:00 – 12:30	Prognostic Significance of Citokeratin Markers in Breast cancer – A Meta Analysis Vivian Barak, Associate Professor in Oncology, Hebrew University, Jerusalem, Israel
		Session 2: Anogenital tumors	Room B	Chairs persons: Luisa L Villa and Anna R. Giuliano
			09:00 – 09:50	Epidemiology of anogenital cancers. Anna R. Giuliano, H. Lee Moffitt Cancer & Center Research Institute, Tampa, USA
			09:50 – 10:30	Carcinogenic role of HPV in anogenital tumors Enrique Boccardo, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil
			10:30 – 11:00	Coffee break
			11:00 – 11:30	Immune responses to HPV infection and cancer. Ligia A. Pinto, National cancer Institute, Maryland, USA
			11:30 – 12:00	HPV vaccination for anogenital cancer prevention Luisa Lina Villa, Medical School, University of São Paulo, São Paulo, Brazil-ICESP
			12:00 – 12:30	Anogenital Cancer Treatment Edmund Chada Baracat, Medical School, University of São Paulo, São Paulo, Brazil
		12:30 – 14:00		Lunch and Poster Session A

Day			Time
Monday, February 4^th ICESP	Concurrent sessions - Molecular biology of cancer: an update 14:00 – 17:00	Room A 14:00 – 14:50		Chairs persons: Roger Chammas Epidemiology in the "omics" era: will the leaves hide the forest? Núria Malats, CNIO, Madrid, Spain
		Session 3: Gastric cancer	Room A	Chairs persons: Ulysses Ribeiro Jr and Ivan Cecconello
			14:50 – 15:30	Familial gastric cancer: overview and guidelines for management. Osmar K. Yagi – Clinics Hospital-Medical School, University of São Paulo, São Paulo, Brazil
			15:30 – 16:00	Gastric stump carcinoma. An experimental model for gastric carcinogenesis? Adriana Vaz Safatle Ribeiro – Clinical Hospital-Medical School, University of São Paulo and ICESP, São Paulo, Brazil
			16:00 – 16:30	Coffee break
			16:30 – 17:00	Targeted therapy in gastric cancer. Renata de Almeida Coudry – Cancer Institute São of Paulo State ICESP
		Session 4: Hepatocellular and pancreatic tumors	Room B	Chairs persons: Venancio Alves and Young N Park
			14:00 – 14:50	Morphological and Molecular characterization of the vascular features of hepatocellular carcinoma from Dysplasia to Advanced Neoplasia Annette Gouw, University Medical Center Groningen, Groningen, Netherlands
			14:50 – 15:30	Hypoxia and Hepatocarcinogenesis, emphasizing the putative role of monocarboxylate transporters Venancio Alves, Medical School, University of São Paulo/ICESP, São Paulo, Brazil
			15:30 – 16:00	A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and EMT. Young N Park, Yonsei University College of Medicine Seodaemun, Seoul, Korea.
			16:00 – 16:30	Coffee break
			16:30 – 17:00	Cholangiocarcinoma and variants – from hilar/large bile duct carcinomas to peripheral ductular carcinomas and hepatocholangiocarcinomas Evandro S Mello, Medical School, University of São Paulo, São Paulo, Brazil
		Room A		Chairs person: Gilberto de Castro
		17:00 -17:30		The PrimerBank database of human and mouse primer pairs for gene expression, detection and quantification Athanasia Spandidos - Medical School, University of Athens, Greece and Harvard Medical School, Boston, USA
		Room B		Chairs person: Nadja Cristhina de Souza Pinto
		17:00 -17:30		DNA repair and Cancer Therapy Carlos FM Menck - Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil
	Conference		17:30 – 18:30	Chair person: Maria A Nagai Ras oncogene and human cancer Demetrios Spandidos, Medical School, University of Crete, Crete, Greece

Day		Time
Tuesday, February 5^th ICESP	Mini-courses 8:00 – 8:45	Room A			MC1 - Immunology for the non-immunologist José Alexandre Barbuto, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil
		Room B			MC2 - Principles of Clinical Research in Oncology Rachel Simoes Pimenta Riechelmann, ICESP, São Paulo, Brazil
		Room C			MC3- 3D culture and mammary gland tumour engraftment as models for studying the biology and therapeutics Bruce Elliott, Queen’s University, Canada
	Concurrent sessions - Molecular biology of cancer: an update 09:00 – 12:30	Session 5: Head and Neck and Lung Cancer		Room A	Chairs persons: Gilberto de Castro and André Lopes Carvalho
				09:00 – 09:50	Predictive lung tumor response to targeted therapies MarileilaVarella-Garcia, School of Medicine, Division of Medical Oncology, University of Colorado Denver, Denver, USA
				09:50 – 10:30	miRNAs as gene regulators in thyroid cancer Edna Teruko Kimura Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil
				10:30 – 11:00	Coffee break
				11:00 – 11:30	Hypermethylation: its role in upper aerodigestive tract carcinogenesis and implications in clinical practice. André Lopes Carvalho, Cancer Hospital of Barretos, Barretos, Brazil
				11:30 – 12:00	Molecular epidemiology of lung câncer Carlos Gil Ferreira, National Institute of Cancer, Rio de Janeiro, Brazil
				12:00 – 12:30	Cancer-stromal interactions in upper aerodigestive cancers Eloiza Helena Tajara da Silva, State of São Paulo University, São José do Rio Preto, Brazil
		Session 6: Hematopoietic tumors		Room B	Chairs persons: Eduardo Rego and Robert Gallagher
				09:00 – 09:50	Molecular heterogeneity considerations in leukemia therapy: lessons from acute promyelocytic leukemia Robert Gallagher, Montefiore Medical Center, Albert Einstein Cancer Center, USA
				09:50 – 10:30	Mitocans as anti-leukemia agent. Eduardo Rego, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil
				10:30 – 11:00	Coffee break
				11:00 – 11:30	Telomere length regulation in hematological malignancies Rodrigo Calado, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil
				11:30 – 12:00	Bone marrow malignancies Sara T. O. Saad, University of Campinas, Campinas, Brazil
				12:00 – 12:30	Tumor Antigens and T-Cell Subpolutations: Possible targets for immunotherapy in lymphoproliferative disorder. Gisele Colleoni, Federal University of São Paulo, São Paulo, Brazil
			12:30 – 14:00		Lunch and Poster Session B

Day		Time
Tuesday, February 5^th ICESP	Concurrent sessions - Molecular biology of cancer: an update 14:00 – 17:30	Room A		Chairs persons: Luisa Lina Villa
		14:00 – 15:00		MicroRNAs in the progression of prostate cancer Anindya Dutta, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA
		Session 7: Prostate cancer	Room A	Chairs persons: Miguel Srougi and Katia Moreira Leite
			15:00 – 15:30	Epigenetics in prostate cancer: biologic and clinical relevance. Katia Moreira Leite, Medical School, University of São Paulo, São Paulo, Brazil
			15:30 – 16:00	Perspectives of Long Non-Coding RNAs in Cancer Diagnostics Eduardo M Reis, Departamento de Bioquímica Instituto de Química - Universidade de São Paulo
			16:00 – 16:30	Coffee break
			16:30 – 17:00	Tumor banks: the cornerstone of basic research in urology. Sabrina Reis, Medical School, University of São Paulo, São Paulo, Brazil
			17:00 – 17:30	Translational research in bladder cancer: from molecular pathogenesis to useful tissue biomarkers. Alberto Azoubel Antunes, Medical School, University of São Paulo, São Paulo, Brazil
		Session 8: Central nervous system tumors	Room B	Chairs persons: Suely K Marie and Gregory Riggins
			14:00 – 14:50	Preclinical development for glioblastoma: Bridging the gap between basic and clinical science Gregory Riggins, Ludwig Collaborative, Baltimore, USA
			14:50 – 15:30	New and old approaches to search for anti-tumor targets of clinical relevance Mari Cleide Sogayar, NUCEL-Cell and Molecular Therapy Center, University of São Paulo, São Paulo, Brazil
			15:30 – 16:00	Central nervous system melatonin production and cancer Regina Pekelmann Markus, Institute of Bioscience, University of São Paulo, São Paulo, Brazil
			16:00 – 16:30	Coffee break
			16:30 – 17:00	Proteomic analysis to search for new therapeutic targets in glioma Jose Cesar Rosa, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil
			17:00 – 17:30	Stem cell markers of medulloblastoma as therapeutic targets Carlos Gilberto Carlotti, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil
	Conference		17:30 – 18:30	Chair person- Roger Chammas New mouse models for in vivo imaging of tumor metastasis: application to gene discovery and drug response in melanoma María S Soengas, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain

Day				Time
Wednesday, February 6^th ICESP		Mini-courses 8:00 – 8:45		Room A				MC1 - Immunology for the non-immunologist José Alexandre Barbuto, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil
				Room B				MC2 - Principles of Clinical Research in Oncology Rachel Simoes Pimenta Riechelmann, ICESP, São Paulo, Brazil
				Room C				MC3 - 3D culture and mammary gland tumour engraftment as models for studying the biology and therapeutics Bruce Elliott, Queen’s University, Canada
		Plenary sessions		9:00 – 12:50				Chairs persons: Paulo H Saldiva and Francisco X Real
						09:00 – 9:50		Environment and cancer Paulo H Saldiva, Medical School, University of São Paulo, São Paulo, Brazil
						9:50 – 10:30		Apoptosis: Extracellular Effects of the Tumor Suppressor Par-4 Vivek Rangnekar, Department of Radiation Medicine, University of Kentucky, Lexington, USA
						10:30 – 11:10		Novel Therapeutic Strategies for Recurrent Prostate Cancer Anna Ferrari, NYU Cancer Institute, New York, USA
						11:10 – 11:30		Coffee break
						11:30 – 12:10		Abnormal O-glycosylation in cancer: from biology to clinical applications Eduardo Osinaga, Faculdad de Medicina, Universidad de la Republica, Montevideo, Uruguay
						12:10 – 12:50		Molecular pathways leading to pancreatic cancer Francisco X. Real, CNIO, Madrid, Spain
						12:50 – 14:00		Lunch
				Oral presentation – selected papers 14:00 – 17:00		14:00 – 14:15		Acetyleugenol nanocapsules impairs in vivo melanoma growth and impairs melanoma cells proliferation and adhesion in vitro. Drewes, C.C., FCF/USP, Brazil
						14:15 – 14:30		Defining the GRB7 interactome in triple-negative breast cancer. Calvo, V., Albert Einstein College of Medicine, USA
						14:30 – 14:45		Use of γH2aX and other biomarkers to quantify distribution of drug activity in solid tumors. Saggar, J.K., University of Toronto, Canada
						14:45 - 15:00		The positive is inside the negative: HER2 negative tumors can present a HER2 positive phenotype, with positive intracytoplasmatic domain and phosphorylated PI3- kinase expression. Panis, C., Instituto Nacional do Câncer, Brazil
						15:00 – 15:15		Expression, activity, and inducibility of pregnane-x- receptor and its role in multidrug-resistance in head and neck squamous cell carcinoma. Rigalli, J.P., University of Heidelberg, Germany
						15:15 – 15:45		Coffee break
						15:45 – 16:00		Iodine maintains Smad4 levels and TGFB responsiveness in BRAF-activated thyroid cells through miR-19 ablation. Fuziwara, C.S., ICb/USP, Brazil
						16:00 – 16:15		NOSH-aspirin (NBS-1120) inhibits breast cancer cell growth in vitro and in vivo: An effect modulated through reactive oxygen species and independent of the ER status. Chattopadhyay, M., City University of New York Medical School, USA
						16:15 – 16:30		Effect of the CIGB-300 synthetic peptide in the modulation of signaling pathways involved with malignant progression of human and murine lung tumors. Cirigliano, S.M., Instituto de Oncología "A. H. Roffo", Argentina
						16:30 - 16:45		Genome wide association study of Hodgkin’s lymphoma. Silva Filho, M.I., German Cancer Research Center, Germany
						16:45 – 17:00		Zeolites as suitable Drug Delivery Systems for anticancer drugs in in vitro models of colorectal carcinoma. Amorim, R., University of Minho, Portugal
		Conference				17:00 – 18:00		Chair person: Roger Chammas Tumor heterogeneity Francisco X. Real , CNIO, Madrid, Spain
Day			Time
Thursday, February 7^th FMUSP Theater	Plenary sessions		Inherited tumors 8:00 – 12:30				Chair persons: Lois M Mulligan and Sergio A Toledo
					08:00 – 09:00		DICER1 mutations result in a surprising array of phenotypes William D Foulkes, McGill University, Montreal, Canada
					09:00 – 09:40		Established and proposed ovarian cancer susceptibility genes Patricia Tonin, McGill University, Montreal, Canada
					09:40 – 10:00		Coffee break
					10:00 – 10:40		Mechanisms of RET Receptor Dysfunction Lois M Mulligan, Queen’s University, Kingston, Canada
					10:40 – 11:20		Management for multiple endrocrine neoplasia typ 2: impact of the RET proto-oncogene analysis Sergio A Toledo, Medical School, University of São Paulo, São Paulo, Brazil
					11:20 – 12:00		The genetic heterogeneity of pheochromocytomas Patricia Dahia, San Antonio Cancer Institute, San Antônio, Texas, USA
					12:00 – 14:00		Lunch
			Advanced Technologies and cancer therapy 14:00 – 18:30				Chair persons: Roger Chammas and Francisco Real
					14:00 – 15:00		Advances in Nanomedicine and Nanotoxicology: Manipulation of Nanomaterials for Diagnostic and Therapy Valtencir Zucolotto Institute of Phisic, University of São Paulo, São Carlos, Brazil
					15:00 – 16:00		Targeted nanoparticles for non-invasive hyperthermia in malignant disease Steven A Curley, MD Anderson Cancer Center in Houston, Texas, USA
					16:00 – 16:30		Coffee break
					16:30 – 17:30		Identification of subtype-specific breast cancer targets using 3D culture models Paraic Kenny, Albert Einstein College of Medicine, New York,USA
					17:30 – 18:30		Reverse engineering multiple myeloma: putting numbers to faces Ariosto Silva, Moffitt Cancer Center, Tampa, FL, USA

Day		Time
Friday, February 8^th	FMUSP Theater	Plenary sessions 08:30 – 12:30		Chair persons: Roger Chammas and Maria A Nagai
			08:30 -09:30	The War on Cancer: Are we winning? Michael J Duffy, School of Medicine & Medical Science, St Vincents University Hospital, Dublin, Ireland
			09:30 – 10:30	Biomarkers for prediction of Metastasis in Melanoma Vivian Barak, Associate Professor in Oncology, Hebrew University, Jerusalem, Israel
			10:30 – 11:00	Coffee break

			11:00 – 11:45	Publishing in Biomedical Sciences. Demetrios Spandidos, Medical School, University of Crete, Crete, Greece
			12:00 – 12:30	Closing Remarks and Departure Roger Chammas, Medical School, University of São Paulo, São Paulo, Brazil Vivek Rangnekar, Department of Radiation Medicine, University of Kentucky, Lexington, USA Michael J Duffy, School of Medicine & Medical Science, St Vincents University Hospital, Dublin, Ireland
	Supervised visit		14:30 – 17:30	Cancer Institute of São Paulo State Medical School of the University of São Paulo Center of Nuclear Medicine

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São Paulo School of Advanced Science

Advances in Molecular Oncology: Translating Molecular Biology into Cancer Treatment