Escola São Paulo de Ciência Avançada

Day

Time

Feb 2^nd

14:00 – 17:30

Check in, credentials, material distribution

Sunday, February 3^rd        FMUSP  Theater

Plenary sessions          9:00  -  18:30

07:30 – 08:45

Check in, credentials, material distribution

09:00 – 09:20

Opening Ceremony and Welcoming Remarks

Prof. Dr. José Otávio Auler

Director in Office of Medical School, University of São Paulo (FMUSP)

Prof Dr Giovanni Guido Cerri

Director of Medical School, University of São Paulo (FMUSP)

Secretary of Health of the State of São Paulo

Prof Dr Marco Antônio Zago

Pro-Chancellor of Research of the University of São Paulo (USP)

Prof Dr José Eluf Neto

Executive Director of the Laboratories of Medical Investigation  (LIMs)

Prof Dr Flavio Fava de Moraes

Director of Medical School Foundation  (FFM)

Prof Dr Carlos Henrique de Brito Cruz

Scientific Director of Foundation for Research Support of São Paulo (FAPESP)

Prof Dr Paulo Hoff

Head of Clinical Oncology- Medical School, University of São Paulo and ICESP Clinical Diretor

Prof Dr Roger Chammas

Head of Basic Oncology- Medical School, University of São Paulo (FMUSP)

Prof Dra Maria A  Nagai

Associate Professor, Medical School, University of São Paulo (FMUSP)

09:30 – 09:40

Paulo Hoff  – Welcome note

Head of Clinical Oncology- Medical School, University of São Paulo and ICESP Clinical Diretor, São Paulo, Brazil

09:40 – 10:20

Carlos Henrique de Brito Cruz

Diretor científico FAPESP, São Paulo, Brazil

10:20 – 10:50

Marco Antônio Zago

Pro-Chancellor of Research of the University of São Paulo (USP), São Paulo, Brazil

10:50 – 11:20

Coffee break

11:20 – 12:20

Opening conference

Molecular Imaging and the tumor microenvironment

Robert Gillies, Moffitt Cancer Center, Tampa, USA

12:20 – 14:00 

Lunch

Chairs persons: José Eluf Neto

14:00 – 15:00

Molecular and immunohistochemical markers of gastric carcinoma differentiation and progression.

Maria de Fátima MH Carneiro – IPATIMUP, Porto, Portugal

15:00 – 16:00

Triple-Negative Breast Cancer: an example for translational cancer research

Fernando Schmitt, IPATMUP, Porto, Portugal

16:00 – 16:30

Coffee break

16:30 – 17:30

Hepatocellular carcinoma – advances in the integration of morphological and molecular aspects, towards a new classification useful for clinical decisions

Park YN, Yonsei University College of Medicine, Seoul, Korea

17:30 – 18:30

Role of biomarkers in cancer detection and patient management

Michael J Duffy, School of Medicine & Medical Science, St Vincents University Hospital, Dublin, Ireland

19:00 – 21:00 (ICESP)

Welcome Cocktail

Day

Time

Monday, February 4^th                            ICESP 

Mini-courses

8:00 – 8:45

Room A

MC1 - Immunology for the non-immunologist

José Alexandre Barbuto, Biomedical Sciences Institute, University of São Paulo,  São Paulo, Brazil

Room B

MC2 - Principles of Clinical Research in Oncology

Rachel Simoes Pimenta Riechelmann, ICESP, São Paulo, Brazil

Room C

MC3 - 3D culture and mammary gland tumour engraftment as models for studying the biology and therapeutics

Bruce Elliott, Queen’s University, Canada

Concurrent sessions -  Molecular biology of cancer: an update          09:00 – 12:30

Session 1: Breast cancer

Room A

Chair persons: M Mitzi Brentani and Maria A Nagai

09:00 – 09:50

Introduction to mammary gland biology and breast cancer

Paraic Kenny,Albert Einstein College of Medicine, Bronx, NY,USA

09:50 – 10:30

The cancer Genome Atlas: Comprehensive  molecular portraits of human tumros

Katherine Hoadley Research Associated, Lineberger Comprehensive Cancer Center, Univ N Carolina, USA

10:30 – 11:00

Coffee break

11:00 – 11:30

Transcriptional profile as prognostic and predictive factor in breast cancer

Maria A K Folgueira, Medical School, University of São Paulo, São Paulo, Brazil

11:30 – 12:00

Molecular alterations mediated by BRCA1 mutations in triple-negative breast tumors

Dirce M Carraro, A C Camargo Hospital, São Paulo, Brazil

12:00 – 12:30

Prognostic Significance of Citokeratin Markers in Breast cancer – A Meta Analysis

Vivian Barak, Associate Professor in Oncology, Hebrew University, Jerusalem, Israel

Session 2: Anogenital tumors

Room B

Chairs persons: Luisa L Villa and Anna R. Giuliano

09:00 – 09:50

Epidemiology of anogenital cancers.

Anna R. Giuliano, H. Lee Moffitt Cancer & Center Research Institute, Tampa, USA

09:50 – 10:30

Carcinogenic role of HPV in anogenital tumors

Enrique Boccardo, Biomedical Sciences Institute, University of São Paulo,  São Paulo, Brazil

10:30 – 11:00

Coffee break

11:00 – 11:30

Immune responses to HPV infection and cancer.

Ligia A. Pinto, National cancer Institute, Maryland, USA

11:30 – 12:00

HPV vaccination for anogenital cancer prevention

Luisa Lina Villa, Medical School, University of São Paulo, São Paulo, Brazil-ICESP

12:00 – 12:30

Anogenital Cancer Treatment

Edmund Chada Baracat, Medical School, University of São Paulo, São Paulo, Brazil

12:30 – 14:00

Lunch and Poster Session A

Day

Time

Monday, February 4^th                            ICESP 

Concurrent sessions -  Molecular biology of cancer: an update              14:00 – 17:00

Room A

14:00 – 14:50

Chairs persons: Roger Chammas

Epidemiology in the "omics" era: will the leaves hide the forest?

Núria Malats, CNIO, Madrid, Spain

Session 3: Gastric cancer

Room A

Chairs persons: Ulysses Ribeiro Jr and Ivan Cecconello

14:50 – 15:30

Familial gastric cancer: overview and guidelines for management.

Osmar K. Yagi – Clinics Hospital-Medical School, University of São Paulo, São Paulo, Brazil

15:30 – 16:00

Gastric stump carcinoma. An experimental model for gastric carcinogenesis?

Adriana Vaz Safatle Ribeiro – Clinical Hospital-Medical School, University of São Paulo and ICESP, São Paulo, Brazil

16:00 – 16:30

Coffee break

16:30 – 17:00

Targeted therapy in gastric cancer.

Renata de Almeida Coudry – Cancer Institute São of Paulo State ICESP

Session 4: Hepatocellular and pancreatic tumors

Room B

Chairs persons: Venancio Alves and Young N Park 

14:00 – 14:50

Morphological and Molecular characterization of the vascular features of hepatocellular carcinoma from Dysplasia to Advanced Neoplasia
Annette Gouw, University Medical Center Groningen, Groningen, Netherlands

14:50 – 15:30

Hypoxia and Hepatocarcinogenesis, emphasizing the putative role
of monocarboxylate transporters

Venancio Alves, Medical School, University of São Paulo/ICESP, São Paulo, Brazil

15:30 – 16:00

A fibrous stromal component in hepatocellular carcinoma reveals a cholangiocarcinoma-like gene expression trait and EMT.
Young N Park, Yonsei University College of Medicine Seodaemun, Seoul, Korea.

16:00 – 16:30

Coffee break

16:30 – 17:00

Cholangiocarcinoma and variants – from hilar/large bile duct carcinomas to peripheral ductular carcinomas and hepatocholangiocarcinomas

Evandro S Mello, Medical School, University of São Paulo, São Paulo, Brazil

Room A

Chairs person: Gilberto de Castro

17:00 -17:30

The PrimerBank database of human and mouse primer pairs for gene expression, detection and quantification

Athanasia Spandidos - Medical School, University of Athens, Greece and Harvard Medical School, Boston, USA

Room B

Chairs person: Nadja Cristhina de Souza Pinto

17:00 -17:30

DNA repair and Cancer Therapy

Carlos FM Menck - Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil

Conference

17:30 – 18:30

Chair person: Maria A Nagai

Ras oncogene and human cancer

Demetrios Spandidos, Medical School, University of Crete, Crete, Greece

Day

Time

Tuesday, February 5^th                                    ICESP

Mini-courses

8:00 – 8:45

Room A

MC1 - Immunology for the non-immunologist

José Alexandre Barbuto, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil

Room B

MC2 - Principles of Clinical Research in Oncology

Rachel Simoes Pimenta Riechelmann, ICESP, São Paulo, Brazil

Room C

MC3- 3D culture and mammary gland tumour engraftment as models for studying the biology and therapeutics

Bruce Elliott, Queen’s University, Canada

Concurrent sessions -  Molecular biology of cancer: an update     09:00 – 12:30

Session 5: Head and Neck and Lung Cancer

Room A

Chairs persons: Gilberto de Castro and André Lopes Carvalho

09:00 – 09:50

Predictive lung tumor response to targeted therapies

MarileilaVarella-Garcia, School of Medicine, Division of Medical Oncology, University of Colorado Denver, Denver, USA

09:50 – 10:30

miRNAs as gene regulators in thyroid cancer

Edna Teruko Kimura Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil

10:30 – 11:00

Coffee break

11:00 – 11:30

Hypermethylation: its role in upper aerodigestive tract carcinogenesis and implications in clinical practice.

André Lopes Carvalho, Cancer Hospital of Barretos, Barretos,  Brazil

11:30 – 12:00

Molecular epidemiology of lung câncer

Carlos Gil Ferreira, National Institute of Cancer, Rio de Janeiro, Brazil

12:00 – 12:30

Cancer-stromal interactions in upper aerodigestive cancers

Eloiza Helena Tajara da Silva, State of São Paulo University, São José do Rio Preto, Brazil

Session 6: Hematopoietic tumors

Room B

Chairs persons: Eduardo Rego and Robert Gallagher

09:00 – 09:50

Molecular heterogeneity considerations in leukemia therapy: lessons from acute promyelocytic leukemia

Robert Gallagher, Montefiore Medical Center, Albert Einstein Cancer Center, USA

09:50 – 10:30

Mitocans as anti-leukemia agent.

Eduardo Rego, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

10:30 – 11:00

Coffee break

11:00 – 11:30

Telomere length regulation in hematological malignancies

Rodrigo Calado, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

11:30 – 12:00

Bone marrow malignancies

Sara T. O. Saad, University of Campinas, Campinas, Brazil

12:00 – 12:30

Tumor Antigens and T-Cell Subpolutations: Possible targets for immunotherapy in  lymphoproliferative disorder.

Gisele Colleoni, Federal University of São Paulo, São Paulo, Brazil

12:30 – 14:00

Lunch and Poster Session B

Day

Time

Tuesday, February 5^th        ICESP

Concurrent sessions -  Molecular biology of cancer: an update     14:00 – 17:30

Room A

Chairs persons: Luisa Lina Villa

14:00 – 15:00

MicroRNAs in the progression of prostate cancer

Anindya Dutta, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA

Session 7: Prostate cancer

Room A

Chairs persons: Miguel Srougi and Katia Moreira Leite

15:00 – 15:30

Epigenetics in prostate cancer: biologic and clinical relevance.

Katia Moreira Leite, Medical School, University of São Paulo, São Paulo, Brazil

15:30 – 16:00

Perspectives of Long Non-Coding RNAs in Cancer Diagnostics

Eduardo M Reis, Departamento de Bioquímica Instituto de Química - Universidade de São Paulo

16:00 – 16:30

Coffee break

16:30 – 17:00

Tumor banks: the cornerstone of basic research in urology.

Sabrina Reis, Medical School, University of São Paulo, São Paulo, Brazil

17:00 – 17:30

Translational research in bladder cancer: from molecular pathogenesis to useful tissue biomarkers.

Alberto Azoubel Antunes, Medical School, University of São Paulo, São Paulo, Brazil

Session 8: Central nervous system tumors

Room B

Chairs persons: Suely K Marie and Gregory Riggins

14:00 – 14:50

Preclinical development for glioblastoma: Bridging the gap between basic and clinical science

Gregory Riggins, Ludwig Collaborative, Baltimore, USA

14:50 – 15:30

New and old approaches to search for anti-tumor targets of clinical relevance

Mari Cleide Sogayar, NUCEL-Cell and Molecular Therapy Center, University of São Paulo, São Paulo, Brazil

15:30 – 16:00

Central nervous system melatonin production and cancer

Regina Pekelmann Markus, Institute of Bioscience, University of São Paulo, São Paulo, Brazil

16:00 – 16:30

Coffee break

16:30 – 17:00

Proteomic analysis to search for new therapeutic targets in glioma

17:00 – 17:30

Carlos Gilberto Carlotti, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil

Conference

17:30 – 18:30

Chair person- Roger Chammas

New mouse models for in vivo imaging of tumor metastasis: application to gene discovery and drug response in melanoma

María S Soengas, Centro Nacional de Investigaciones Oncológicas, Madrid, Spain

Day

Time

Wednesday, February 6^th                                    ICESP

Mini-courses

8:00 – 8:45

Room A

MC1 - Immunology for the non-immunologist

José Alexandre Barbuto, Biomedical Sciences Institute, University of São Paulo, São Paulo, Brazil

Room B

MC2 - Principles of Clinical Research in Oncology

Rachel Simoes Pimenta Riechelmann, ICESP, São Paulo, Brazil

Room C

MC3 - 3D culture and mammary gland tumour engraftment as models for studying the biology and therapeutics

Bruce Elliott, Queen’s University, Canada

Plenary sessions

9:00 – 12:50   

Chairs persons: Paulo H Saldiva and Francisco X Real

09:00 – 9:50

Environment and cancer

Paulo H Saldiva, Medical School, University of São Paulo, São Paulo, Brazil

9:50 – 10:30

Apoptosis: Extracellular Effects of the Tumor Suppressor Par-4

Vivek Rangnekar, Department of Radiation Medicine, University of Kentucky, Lexington, USA

10:30 – 11:10

Novel Therapeutic Strategies for Recurrent Prostate Cancer

Anna Ferrari, NYU Cancer Institute, New York, USA

11:10 – 11:30

Coffee break

11:30 – 12:10

Abnormal O-glycosylation in cancer: from biology to clinical applications

Eduardo Osinaga, Faculdad de Medicina, Universidad de la Republica, Montevideo, Uruguay

12:10 – 12:50

Molecular pathways leading to pancreatic cancer

Francisco X. Real, CNIO, Madrid, Spain

12:50 – 14:00

Lunch

Oral presentation – selected papers

14:00 – 17:00

14:00 – 14:15

Acetyleugenol nanocapsules impairs in vivo melanoma growth and impairs melanoma cells proliferation and adhesion in vitro. Drewes, C.C., FCF/USP, Brazil

14:15 – 14:30

Defining the GRB7 interactome in triple-negative breast cancer. Calvo, V., Albert Einstein College of Medicine, USA

14:30 – 14:45

Use of γH2aX and other biomarkers to quantify distribution of drug activity in solid tumors. Saggar, J.K., University of Toronto, Canada

14:45 -  15:00

The positive is inside the negative: HER2 negative tumors can present a HER2 positive phenotype, with positive intracytoplasmatic domain and phosphorylated PI3- kinase expression. Panis, C., Instituto Nacional do Câncer, Brazil

15:00 – 15:15

Expression, activity, and inducibility of pregnane-x- receptor and its role in multidrug-resistance in head and neck squamous cell carcinoma. Rigalli, J.P., University of Heidelberg, Germany

15:15 – 15:45

Coffee break

15:45 – 16:00

Iodine maintains Smad4 levels and TGFB responsiveness in BRAF-activated thyroid cells through miR-19 ablation. Fuziwara, C.S., ICb/USP, Brazil

16:00 – 16:15

NOSH-aspirin (NBS-1120) inhibits breast cancer cell growth in vitro and in vivo: An effect modulated through reactive oxygen species and independent of the ER status. Chattopadhyay, M., City University of New York Medical School, USA

16:15 – 16:30

Effect of the CIGB-300 synthetic peptide in the modulation of signaling pathways involved with malignant progression of human and murine lung tumors. Cirigliano, S.M., Instituto de Oncología "A. H. Roffo", Argentina

16:30 -  16:45

Genome wide association study of Hodgkin’s lymphoma.  Silva Filho, M.I., German Cancer Research Center, Germany

16:45 – 17:00

Zeolites as suitable Drug Delivery Systems for anticancer drugs in in vitro models of colorectal carcinoma. Amorim, R., University of Minho, Portugal

Conference

17:00 – 18:00

Chair person: Roger Chammas

Tumor heterogeneity

Francisco X. Real , CNIO, Madrid, Spain

Day

Time

Thursday, February 7^th      FMUSP Theater

Plenary sessions    

Inherited tumors

8:00 – 12:30

Chair persons: Lois M Mulligan and  Sergio A Toledo

08:00 – 09:00

DICER1 mutations result in a surprising array of phenotypes

William D Foulkes, McGill University, Montreal, Canada

09:00 – 09:40

Established and proposed ovarian cancer susceptibility genes

Patricia Tonin, McGill University, Montreal, Canada

09:40 – 10:00

Coffee break

10:00 – 10:40

Mechanisms of RET Receptor Dysfunction

Lois M Mulligan, Queen’s University, Kingston, Canada

10:40 – 11:20

Management for multiple endrocrine neoplasia typ 2: impact of the RET proto-oncogene analysis

Sergio A Toledo, Medical School, University of São Paulo, São Paulo, Brazil

11:20 – 12:00

The genetic heterogeneity of pheochromocytomas

Patricia Dahia, San Antonio Cancer Institute, San Antônio, Texas, USA

12:00 – 14:00 

Lunch

Advanced Technologies and cancer therapy

14:00 – 18:30

Chair persons: Roger Chammas and Francisco Real

14:00 – 15:00

Advances in Nanomedicine and Nanotoxicology: Manipulation of Nanomaterials for Diagnostic and Therapy

Valtencir Zucolotto Institute of Phisic, University of São Paulo, São Carlos, Brazil

15:00 – 16:00

Targeted nanoparticles for non-invasive hyperthermia in malignant disease

Steven A Curley, MD Anderson Cancer Center in Houston, Texas, USA

16:00 – 16:30

Coffee break

16:30 – 17:30

Identification of subtype-specific breast cancer targets using 3D 
culture models

Paraic Kenny, Albert Einstein College of Medicine, New York,USA

17:30 – 18:30

Reverse engineering multiple myeloma: putting numbers to faces

Ariosto Silva, Moffitt Cancer Center, Tampa, FL, USA 

Day

Time

Friday, February 8^th

FMUSP Theater  

Plenary sessions      08:30 – 12:30

Chair persons: Roger Chammas and Maria A Nagai

08:30 -09:30

The War on Cancer: Are we winning?

Michael J Duffy, School of Medicine & Medical Science, St Vincents University Hospital, Dublin, Ireland

09:30 – 10:30

Biomarkers for prediction of Metastasis in Melanoma

Vivian Barak, Associate Professor in Oncology, Hebrew University, Jerusalem, Israel

10:30 – 11:00

Coffee break

11:00 – 11:45

Publishing in Biomedical Sciences.

Demetrios Spandidos, Medical School, University of Crete, Crete, Greece

12:00 – 12:30

Closing Remarks and Departure

Roger Chammas, Medical School, University of São Paulo, São Paulo, Brazil

Vivek Rangnekar, Department of Radiation Medicine, University of Kentucky, Lexington, USA

Michael J Duffy, School of Medicine & Medical Science, St Vincents University Hospital, Dublin, Ireland

Supervised visit

14:30  – 17:30

Cancer Institute of São Paulo State 

Medical School of the University of São Paulo 

Center of Nuclear Medicine