Escola São Paulo de Ciência Avançada

April 19^{th –} Monday 

9:00 – 10:00 AM

            Registration and welcome breakfast 

10:00 - 11:00 AM

            Opening section: RR Brentani: Research and teaching at a private hospital. 

11:00 – 11:45 AM

            CH Brito-Cruz: FAPESP: Science and Technology in São Paulo. 

11:45 – 12:30  PM

            R Pasqualini: Mapping molecular diversity by in vivo phage display. 

12:30 – 2:30 PM

            Lunch 

2:30 – 3:15 PM

            W Arap: The human vascular mapping project. 

3:15 – 4:00 PM

            R Drmanac: Medical genomics as the foundation of personalized disease prevention and treatments 

4:00 – 4:20 PM

            Coffee break  

4:20 – 5:05 PM

            R Seeley: How obesity went to our heads:  CNS regulation of energy balance 

5:30 PM

            Welcome cocktail
 

April 20^{th –} Tuesday 

9:00 – 9:45 AM

W Cavenee: Improving cancer therapy targeted at mutant receptors 

9:45 – 10:30 AM

            W Arap: Ligand-directed targeting and molecular imaging in translational medicine 

10:30 – 10:50 AM

            Coffee break 

10:50 – 11:35 AM

R Drmanac: Understanding genetic and molecular basis of human diseases by sequencing one million human genomes 

11:35 – 12:20  PM

            R Seeley: Gut-brain communication in obesity and diabetes

12:20  – 1:40  PM
            Lunch 

1:40 – 3:20 PM

            Selected oral presentations

- Sergio Iadevaia, MD Anderson Cancer Center, Houston, USA: Identification of optimal drug combinations targeting cellular networks: integrating phospho-proteomics and computational network analysis.

- Avaduth Joshi, Johns Hopkins University, Baltimore, USA: Combined receptor tyrosine kinase inhibition of glioblastoma multiforme.

- Alexandre JN Trindade, Universidade Técnica de Lisboa, Lisboa, Portugal: DLL4 inhibition therapy can accelerate wound healing by inducing functional neo-angiogenesis: a matter of dosage. 

3:20 – 3:45 PM

            Coffee break 

3:45 – 4:30 PM

            R Pasqualini: Vascular and lymphatic targeting: pre-clinical and clinical drug development updates 
 

April 21^st – Wednesday 

9:00 -9:45 AM

            VR Martins: Prions: infectious mechanism and diseases 

9:45 – 10:30 AM

R Linden: The prion protein and the immune system - and the other way around 

10:30 – 11:00 AM

            Coffee break 

11:00 – 11:45 AM

MA Prado: Yin and Yang of prion protein biology. 

11:45 – 1:00  PM

Selected oral presentations

- Flavio HB Paiva, Robarts Res. Institute, London, Canada: Prion protein transduces signals after binding to laminin chain via metabrotopic glutamate receptors.

- Bruno Costa da Silva, Ludwig Institute for Cancer Research, São Paulo, Brazil: Functional relevance of cellular prion protein (PrPC) and Hsp70/Hsp90 organizing protein (STI1/HOP) in colorectal and pancreatic tumors.

- Ana Cristina R Magalhães, Robarts Res. Institute, London, Canada: CRF receptor 1 regulates anxiety behaviour via sensitization of 5-HT2 receptor signaling.

- Maria Galli de Amorim, Philadelphia, USA: Modeling Rett syndrome with genetically modified mice. 

1:00 – 2:00 PM

            Lunch 

2:00 – 2:45 PM

            VR Martins: Prion protein as a therapeutic target in cancer 

2:45 – 3:30 PM

            R Linden: Neuroprotection by the transcription factor Max: Towards gene therapy for glaucoma 

3:30 – 4:15 PM

            Coffee break 

4:15 – 5:00 PM

MA Prado: The use of genetically modified mice to model and understand human diseases. 

April 22^{nd –} Thursday 

9:00 -9:45 AM

A Bardelli: The genetic basis of response to EGFR targeted therapies in CRCs. 

9:45 – 10:45 AM

Oral Presentations

- Rachid A. Karam, University of California San Diego, San Diego, USA: Coupling of RNA and protein quality controls in cancer.

- Curtis Pickering, MD Anderson Cancer Center, Houston, USA: Profiling tongue squamous cell carcinoma to understand tumor formation, lymph node metastasis and drug resistance.

- Gustavo de Campos Molina, Hospital AC Camargo, São Paulo, Brazil: Combination of an enzyme restriction and barcode method for transcriptional assessment in 454-platform. 

10:45 – 11:15 AM

            Coffee break 

11:15 – noon

SR Rogatto: Integrative genomic and transcriptomic analysis of uterine leyomiomas 

noon – 12:45 PM

P Stankiewicz: Mechanisms of DNA rearrangements underlying genomic disorders 

12:45- 1:45

            Lunch 

1:45 – 2:15

            Oral presentations:

- Francine Blumental de Abreu, Hospital AC Camargo, São Paulo, Brazil: 3p12.3 and 7q36.3 harbor genes associated with hereditary breast and colorectal carcinomas.

- Melanie Heney, Baylor College of Medicine, Houston, USA: Using a mouse copy number variation (CNV)-engineering system to study neurobehavioral and metabolic phenotypes in two genomic disorders SMS and PTLS 

2:15 – 3:00 PM

            P Stankiewicz: Molecular mechanisms and clinical consequences of genomic disorders. 

3:00 – 3:45 PM

C Rosenberg : Advances in the diagnosis of mental retardation: from karyotyping to molecular cytogenetics. 

3:45 – 4:15 PM

            Coffee break

4:15 – 5:00 PM

            SR Rogatto: Copy number alterations in hereditary breast and colorectal cancer syndromes
 

April 23^rd – Friday 

9:00 -9:45 AM

A Bardelli: Isogenic mutant human cells: A new tool for personalized cancer medicine. 

9:45 – 10:30 AM

            D Lyden: The switch between angiogenesis and vasculogenesis for tumor growth and metastases 

10:30 – 10:50 AM

            Coffee break 

10:50 – 11:35 AM

D Lyden: The pre-metastatic niche: a permissive microenvironment for metastasis. 

11:35  – 12:20 PM

A Coutinho: Mechanisms of natural immunological tolerance: implications for cancer immunotherapy 

12:20 - 1:05 PM

            A Coutinho: Integrating evolutionary layers of host protection: immunity and tolerance 

Free Afternoon


April 26^th – Monday 

9:45 – 10:30 AM

            O Podhajcer: Role of matricellular protein in cancer progression.           

10:30 – 10:50 AM

            Coffee break 

10:50 – 11:35 AM

            LP Kowalski: Oropharynx cancer: chemoradiation or surgery? 

11:35 – 12:20 PM

            A Lopes: Penile carcinoma, clinical aspects, treatment and prognostic factors 

12:20 – 1:30  PM

            Lunch 

1:30 – 2:30 PM

Oral Presentations

- Di Ai, University of Texas, Houston, USA: Cardiomyocyte PDGFR-b signaling is an essential component of the mouse cardiac response to load-induced stress.

- Márcio L. Acêncio, UNESP, Botucatu, Brazil: In silico network-based discovery of candidate RB-E2F axis-independent signaling pathways involved in the cell-matrix adhesion-mediated control of G1/S cell cycle transition.

- Carla Abdo Brohem, Universidade de São Paulo, São Paulo, Brazil: Mechanism of action of 4-nerolidylcathecol: induction of apoptosis via ROS accumulation and inhibition of invasion in melanoma and skin reconstructs model.

- Mauro SG Pavão, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil: oversulfated dermatan sulfate from ascidians, but not its mammalian counterpart, inhibits p-selectin in vitro and metastasis in vivo.

 2:30 – 3:15 PM

            J Kobarg: The role of Nek family kinases in cell cycle progression and DNA damage responses. 

3:15 – 3:45 PM

Coffee break 

3:45 – 4:30 PM

            S Rehen: Embryonic and pluripotent stem cells as tools for studying neurogenesis 

4:30 – 5:15 PM

            R Chammas: Functional significance of carbohydrate-dependent tumor associated antigens 

5:15 – 6:00 PM

FA Soares: Morphological aspects of the EMT phenomenon
 

April 27^th - Tuesday 

9:00 -9:45 AM

Bettina Weigelin, Nijmegen, Netherlands: Dynamic imaging of the tumor microenvironment: impact on invasion and CTL effector function.

9:45 – 10:30 AM

J Kobarg: The human microtubule transport adaptor protein FEZ1 is involved in the formation of “flower-like” nuclei. 

10:30 – 10:50 AM

            Coffee break 

10:50 – 11:35 AM

            S Rehen: Neural differentiation is followed by aneuploidy in embryonic and induced pluripotent cells 

11:35 – 12:50 PM

            Oral presentations

- Luciane Fragel Madeira, Universidade Federal Fluminense, Rio de Janeiro, Brazil: A check-point induced by platelet activating factor arrests retinal progenitors at the S/G2 cell cycle transition.

- Patrícia M. Machado, Instituto Português de Oncologia de Lisboa, Lisboa, Portugal: BRCA1/2 genetic screening in Portuguese high-risk breast/ovarian cancer families.

- Alisson M Burton, MD Anderson Cancer Center, Houston, USA: Health and life-style behaviors among persons at risk for Lynch syndrome.

- Edenir Inez Palmero, Hospital de Câncer de Barretos, Barretos, Brazil: TP53, PIN3 and MDM2 SNP309 polymorphism as genetic modifiers in the Li-Fraumeni syndrome: impact on age at first diagnosis.

- Sofia Braga, Instituto Gulbenkian de Ciência, Oeiras, Portugal: Heterogeneity of triple negative breast cancer.

12:50 – 1:50 PM

            Lunch 

1:50 – 2:35 PM

            P Hainaut: TP53 suppressor gene: from genomics to clinical applications. 

2:35 – 3:20 PM

MI Achatz: Managing families with inherited cancer; High prevalence of R337H mutation in Brazilian LFS/LFL families. 

3:20 – 3:50 PM

            Coffee break 

3:50 – 4:35 PM

            P Ashton-Prolla: Genetic counseling in inherited predisposition cancer syndromes 

4:35 – 5:20 PM

            D Malkin: The role of DNA copy number variation in childhood cancer susceptibility. 

5:20 – 6:05 PM

            FA Soares: Tumor differentiation – phenotypic/genotypic relationships 

April 28^th – Wednesday (new) 

9:30 – 10:15 AM

            O Podhajcer: Oncolytic vectors in cancer therapy 

10:15 – 10:30 AM

Coffee break 

10:30 – 11:15 AM

R Tuder: Interplay between alveolar cell apoptosis, oxidative stress, and senescence in cigarette smoke-induced pulmonary diseases 

11:15 – 12:15 PM    Oral presentations

- Cintia Yoko Morioka, Toyama Medical and Pharmaceutical University, Toyama, Japan. Anti-sense oligonucleotide matching k-ras gene in hamster pancreatic cancer model in-vitro and in-vivo – Is it possible?

- Pedro MP Coelho, Depto de Anatomia, Univ. Federal do Rio de Janeiro, Rio de Janeiro, Brazil. Cell therapy in a rodent model of neonatal hypoxic-ischemic encephalopathy.

- Agda Karina Eterovic, University of Texas Health Science Center, Houston, USA. Mediators of glioblastoma resistance and invasion during anti-VEGF therapy.

- Valerie LeBleu, Harvard Medical School Boston, USA. Disruption of tumor angiogenesis leads to increased metastasis due to HIF1a/CD44/p38 MAP kinase mediated epithelial to mesenchymal transition. 

12:15 – 1:30  PM

Lunch 

1:30 – 2:15 PM

            R Kalluri: Systemic angiogenesis balance and tumor microenvironment. 

2:15 – 3:00 PM

R Tuder: Abnormal angiogenesis and disregulated growth of pulmonary endothelial cells in pulmonary hypertension. 

3:00 – 3:30 PM

Coffee break 

3:30 – 4:15 PM

R Giordano: Development of anti-angiogenic compounds: Phage-display and the angiogenic retina as a model 

4:15 – 5:00 PM

            I Izquierdo: Memory consolidation 

5:00 – 5:45 PM

            DI Smith: Developing the infrastructure for next-generation DNA sequencing at the Mayo clinic 
 

April 29^th – Thursday 

9:00 -9:45 AM

R Costa: Neural mechanisms of action learning: from intent to habit 

9:45 – 10:30 AM

            Z Mainen: Sensory perception: Lessons from the olfactory system of the rat 

10:30 – 11:00 AM

            Coffee break 

11:00 – 12:15 AM

            Oral presentations

- Angela A. Fachel, Universidade de Sao Paulo, Sao Paulo, Brazil.  Long intronic non-coding RNA signatures of malignancy and survival outcome in clear cell renal carcinoma.

- Barbara Pereira de Melo, Hospital AC Camargo, Sao Paulo, Brazil. No-match ORESTES explored as non-coding tumor markers.

- Gustavo J. Rodrigues, Baylor College of Medicine, Houston, USA. Allosteric communication within the dopamine D2 receptor: evolution-guided retooling receptor activation specificity.

- Frederico R. Ferreira, Faculdade de Medicina, Universidade de Sao Paulo, Ribeirao Preto, Brazil. Effects of treatment with 7-nitroindazole (7NI), a neuronal NO synthase inhibitor, or imipramine on protein and gene expression in the hippocampus of rats submitted to the forced swimming test.

- Janine Inez Rossato, Instituto do Cérebro, PUC-RS, Porto Alegre, Brazil. On the reconsolidation of extinction memory. 

12:15 – 1:30 PM

Lunch 

1:30 – 2:15  PM

            V Moura-Neto: Cross-talk between parenchyma and glial cells: highlights in brain tumors 

2:15 – 3:00 PM

            I Izquierdo: Memory persistence I 

3:00 – 3:45 PM

            I Izquierdo: Memory persistence II 

3:45 – 4:15 PM

            Coffee break 

4:15 – 5:00 PM

            R Costa: Generating action sequences 

5:00 – 5:45 PM

            Z Mainen: Decision-making: Executing and monitoring decisions under uncertainty 

5:45 – 6:45 PM

            Diego Olego: Technical innovations in oncology